Vainio H, Coleman M, Wilbourn J
Unit of Carcinogen Identification and Evaluation, International Agency for Research on Cancer, Lyon, France.
Environ Health Perspect. 1991 Dec;96:5-9. doi: 10.1289/ehp.91965.
Many thousands of chemicals are produced industrially and many more occur naturally. Information on the toxicology of these chemicals is often minimal or absent. The International Agency for Research on Cancer (IARC) has published evaluations of the carcinogenic risk to humans of over 700 chemicals, groups of chemicals, and complex mixtures as a regular series of monographs. A database has been created containing summaries of all the relevant epidemiological, animal carcinogenicity, and other relevant biological data for each chemical or mixture evaluated. Additional databases have been created for ongoing epidemiological studies of cancer in humans and for long-term carcinogenicity studies in rodents, as well as a database containing information on genotoxic and related effects of chemicals. Some of these databases have been published in print form. IARC now plans to publish them electronically, together with other databases, in the form of a CDROM (compact disk, read-only memory). The objective will be to make the entire IARC database of cancer information as widely available as possible in an integrated format conducive to efficient and combined exploitation of all the component databases.
数千种化学物质是通过工业生产制造出来的，还有更多的化学物质是天然存在的。关于这些化学物质的毒理学信息往往极少，甚至完全没有。国际癌症研究机构（IARC）定期出版一系列专著，对700多种化学物质、化学物质群组及复杂混合物对人类的致癌风险进行了评估。现已创建了一个数据库，其中包含对每种已评估的化学物质或混合物的所有相关流行病学、动物致癌性及其他相关生物学数据的总结。还为正在进行的人类癌症流行病学研究和啮齿动物长期致癌性研究创建了额外的数据库，以及一个包含化学物质遗传毒性及相关效应信息的数据库。其中一些数据库已以印刷形式出版。IARC现在计划以只读光盘（CD-ROM）的形式将它们与其他数据库一起以电子方式出版。目标是使整个IARC癌症信息数据库以一种便于有效综合利用所有组成数据库的集成格式尽可能广泛地提供。
