Vainio H, Hemminki K, Wilbourn J
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Data were extracted from IARC Monographs volumes 1-38 on chemicals and exposures for which some data on carcinogenicity in humans, or sufficient evidence of carcinogenicity in experimental animals existed. In all, 288 chemicals, industrial processes and complex mixtures fulfilled these criteria. For 30 chemicals or mixtures of chemicals, and nine industrial processes, there was sufficient evidence of carcinogenicity in humans; and for 63 chemicals and mixtures of chemicals and for five industrial processes, there was evidence that these exposures were probably carcinogenic to humans. For 61 chemicals or groups of chemicals and six industrial processes or occupations, no evaluation of carcinogenicity to humans could be made. For 115 chemicals there is sufficient evidence of carcinogenicity to experimental animals, but no epidemiological data are available. Publications not earlier referred to on the carcinogenicity of these chemicals and exposures were found for approximately 70. A call is made for further information on these exposures with a view to updating the IARC Monographs.
数据取自国际癌症研究机构(IARC)《专论》第1 - 38卷,涉及那些在人类致癌性方面有一些数据,或在实验动物中有充分致癌证据的化学物质和暴露因素。总共有288种化学物质、工业过程和复杂混合物符合这些标准。对于30种化学物质或化学物质混合物以及9种工业过程,有充分的人类致癌证据;对于63种化学物质和化学物质混合物以及5种工业过程,有证据表明这些暴露因素可能对人类致癌。对于61种化学物质或化学物质组以及6种工业过程或职业,无法对其对人类的致癌性进行评估。对于115种化学物质,有充分的实验动物致癌证据,但尚无流行病学数据。大约发现了70篇此前未提及这些化学物质和暴露因素致癌性的出版物。呼吁提供有关这些暴露因素的更多信息,以便更新IARC《专论》。