Ermakova G N, Nefelova M V, Egorov N S
Antibiotiki. 1976 Jul;21(7):596-600.
A synthetic medium containing optimal levels of the sources of carbon, nitrogen and inorganic phosphorus and providing satisfactory yields of polymyxin B was developed for 2 strains of Bac. polymyxa 933 and VK-153. The consumption of phosphorus in the medium by the strains and the antibiotic biosynthesis levels depended on the form of phosphorus added to the medium. Optimal biosynthesis of polymyxin B was observed at lower concentration levels of soluble soluble phosphorus in the medium than the bacterial growth.
为多粘芽孢杆菌933和VK - 153这两株菌株开发了一种合成培养基，该培养基含有最佳水平的碳源、氮源和无机磷源，能产生令人满意的多粘菌素B产量。菌株对培养基中磷的消耗以及抗生素生物合成水平取决于添加到培养基中的磷的形式。在培养基中可溶性磷浓度低于细菌生长所需浓度时，观察到多粘菌素B的最佳生物合成。
