Proteomics Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Egyetem tér 1, 4032 Debrecen, Hungary.
Biomarker Research Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Egyetem tér 1, 4032 Debrecen, Hungary.
Int J Mol Sci. 2020 Dec 15;21(24):9547. doi: 10.3390/ijms21249547.
(1) Background: Wine contains a variety of molecules with potential beneficial effects on human health. Our aim was to examine the wine components with high-resolution mass spectrometry including high-resolution tandem mass spectrometry in two wine types made from grapes with or without the fungus , or "noble rot". (2) For LC-MS/MS analysis, 12 wine samples (7 without and 5 with noble rotting) from 4 different wineries were used and wine components were identified and quantified. (3) Results: 288 molecules were identified in the wines and the amount of 169 molecules was statistically significantly different between the two wine types. A database search was carried out to find the molecules, which were examined in functional studies so far, with high emphasis on molecules with antiviral, anti-inflammatory and anticancer activities. (4) Conclusions: A comprehensive functional dataset related to identified wine components is also provided highlighting the importance of components with potential health benefits.
（1）背景：葡萄酒中含有多种对人体健康可能有益的分子。我们的目的是使用高分辨率串联质谱（包括高分辨率质谱）检测两种葡萄酒类型中的葡萄酒成分，这两种葡萄酒是由带有或不带有真菌（或“贵腐菌”）的葡萄制成的。（2）对于 LC-MS/MS 分析，使用了来自 4 个不同酿酒厂的 12 个葡萄酒样本（7 个无贵腐菌和 5 个有贵腐菌），并对葡萄酒成分进行了鉴定和定量。（3）结果：在葡萄酒中鉴定出 288 种分子，两种葡萄酒类型之间有 169 种分子的数量存在统计学显著差异。进行了数据库搜索，以找到迄今为止在功能研究中检查过的分子，特别强调具有抗病毒、抗炎和抗癌活性的分子。（4）结论：还提供了与鉴定出的葡萄酒成分相关的综合功能数据集，突出了具有潜在健康益处的成分的重要性。
