Tan Kiat Tsong, Lip Gregory Y H
University of Bristol, Department of Radiology, Bristol Royal Infirmary, Bristol BS2 8HW, England, United Kingdom.
Int J Cardiol. 2008 Jul 4;127(2):157-65. doi: 10.1016/j.ijcard.2007.11.054. Epub 2008 Jan 22.
Atherosclerosis is now considered a systemic inflammatory disorder affecting the arterial tree. Inflammation plays a role in all stages of the disease, from the initiation of the fatty streak to the final stage of plaque rupture. Atherosclerotic plaques that demonstrate the features of active inflammation are more likely to become symptomatic. In addition to having a higher risk of developing adverse cardiovascular events, patients who have higher indices of inflammation may be more likely to develop restenosis after endovascular stenting. Thus, the identification of the 'inflamed plaque' is the subject of intense research. The detection of the inflamed plaque by the conventional modalities of ultrasound, magnetic resonance imaging, computed tomography and nuclear medicine as well as the novel imaging modalities of optical coherence tomography, near-infrared spectroscopy, thermography and angioscopy will be examined.
动脉粥样硬化现在被认为是一种影响动脉系统的全身性炎症性疾病。炎症在疾病的各个阶段都发挥作用，从脂肪条纹的形成到斑块破裂的最后阶段。表现出活跃炎症特征的动脉粥样硬化斑块更有可能出现症状。除了发生不良心血管事件的风险更高外，炎症指标较高的患者在血管内支架置入术后更有可能发生再狭窄。因此，“炎症斑块”的识别是深入研究的主题。将探讨通过超声、磁共振成像、计算机断层扫描和核医学等传统方式以及光学相干断层扫描、近红外光谱、热成像和血管内镜等新型成像方式检测炎症斑块的情况。
