¹⁸F-FDG PET/CT对诊断性¹²³I扫描阴性且甲状腺球蛋白升高的分化型甲状腺癌患者的临床意义
Clinical implication of F-18 FDG PET/CT for differentiated thyroid cancer in patients with negative diagnostic iodine-123 scan and elevated thyroglobulin.
作者信息
Kim Seong-Jang, Lee Tae Hong, Kim In-Ju, Kim Yong-Ki
机构信息
Department of Nuclear Medicine, Pusan National University Hospital, Busan, Republic of Korea.
出版信息
Eur J Radiol. 2009 Apr;70(1):17-24. doi: 10.1016/j.ejrad.2007.12.004. Epub 2008 Jan 18.
UNLABELLED
This study aims to investigate the usefulness of F-18 FDG PET/CT in differentiated thyroid cancer (DTC) with elevated serum thyroglobulin (Tg) but negative iodine-123 (I-123) scan.
METHODS
Twenty patients with histopathologically proven DTC, negative diagnostic I-123 scan, and elevated serum Tg levels were prospectively submitted to F-18 FDG PET/CT evaluation. The histopathologic findings consisted of 19 papillary thyroid cancers, 1 follicular thyroid cancer.
RESULTS
F-18 FDG PET/CT identified lesions in 18 out of 20 patients, giving a sensitivity of 90%. Thirteen of the 18 patients revealed limited loco-regional disease. Remaining 5 patients showed distant metastases, consisting of 4 patients with lung metastases and 1 patient with bone metastasis. Two patients revealed negative F-18 FDG PET/CT findings.
CONCLUSION
F-18 FDG PET/CT is suitable for the detection and precise localization of loco-regional recurrences and distant metastases of DTC in patients with elevated serum Tg but negative I-123 whole body scan.
未标记
本研究旨在探讨F-18 FDG PET/CT在血清甲状腺球蛋白（Tg）升高但碘-123（I-123）扫描阴性的分化型甲状腺癌（DTC）中的应用价值。
方法
对20例经组织病理学证实为DTC、诊断性I-123扫描阴性且血清Tg水平升高的患者进行前瞻性F-18 FDG PET/CT评估。组织病理学结果包括19例乳头状甲状腺癌和1例滤泡状甲状腺癌。
结果
F-18 FDG PET/CT在20例患者中的18例发现了病变，敏感性为90%。18例患者中的13例显示局部区域疾病局限。其余5例患者出现远处转移，包括4例肺转移患者和1例骨转移患者。2例患者F-18 FDG PET/CT检查结果为阴性。
结论
F-18 FDG PET/CT适用于血清Tg升高但I-123全身扫描阴性的DTC患者局部区域复发和远处转移的检测及精确定位。
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