Becker R
Grünthal GmbH, Centre of ResearchAachen, F.R.G.
Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:15-6.
MRT was derived as the mean value of the continuously distributed random variable residence time. Provide that elimination kinetics is linear and that elimination takes place exclusively from the central compartment, MRT can be calculated from the ratio AUMC/AUC. In this case, MRT is a drug (and formulation) related constant MRT may also be determined when the elimination kinetics is nonlinear. The meaning of those MRT values, however, remains limited because they depend on the dose applied.
平均滞留时间（MRT）是作为连续分布的随机变量滞留时间的平均值推导出来的。假设消除动力学是线性的，并且消除仅发生在中央室，则MRT可以从血药浓度-时间曲线下面积（AUC）与一阶矩曲线下面积（AUMC）的比值计算得出。在这种情况下，MRT是一个与药物（和制剂）相关的常数。当消除动力学为非线性时，也可以确定MRT。然而，这些MRT值的意义仍然有限，因为它们取决于所应用的剂量。
