甾体激素对体外培养人成纤维细胞的作用。II. 雄激素对皮质醇诱导抑制的拮抗作用
Effects of steriod hormones on human fibroblasts in vitro. II. Antagonism by androgens of cortisol-induced inhibition.
作者信息
Harvey W, Grahame R, Panayi G S
出版信息
Ann Rheum Dis. 1976 Apr;35(2):148-51. doi: 10.1136/ard.35.2.148.
Abstract
Inhibition of dermal activity by cortisol in culture was partially reversed by two naturally occurring androgens, testosterone and dihydrotestosterone. ACTH and the androgen precursor dehydroepiandrosterone sulphate showed not such antagonistic effect. These results suggest that increased production of adrenal androgens during ACTH therapy may account for the relative absnece of 'skin-thinning' and 'steroid-bruising' which are common side-effects of corticosteroid therapy.
摘要
在培养过程中，皮质醇对皮肤活性的抑制作用被两种天然存在的雄激素——睾酮和双氢睾酮部分逆转。促肾上腺皮质激素（ACTH）和雄激素前体硫酸脱氢表雄酮未表现出这种拮抗作用。这些结果表明，ACTH治疗期间肾上腺雄激素产量增加可能是皮质类固醇治疗常见副作用“皮肤变薄”和“类固醇瘀伤”相对不存在的原因。
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本文引用的文献
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Corticosteroid bruising.皮质类固醇性瘀斑
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A comparative study of the conversion of testosterone to 17-beta-hydroxy-5-alpha-androstan-3-one (Dihydrotestosterone) by prostate and epididymis.前列腺和附睾将睾酮转化为17-β-羟基-5-α-雄甾烷-3-酮（双氢睾酮）的比较研究。
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