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1
Osteoporosis, skin collagen, and androgen.骨质疏松症、皮肤胶原蛋白与雄激素。
Br Med J. 1970 Dec 26;4(5738):773-4. doi: 10.1136/bmj.4.5738.773.
2
Osteoporosis, like skin ageing, is caused by collagen loss which is reversible.骨质疏松症与皮肤老化一样，是由可逆转的胶原蛋白流失引起的。
J R Soc Med. 2020 Apr;113(4):158-160. doi: 10.1177/0141076820910315.
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Skin collagen and thickness in women with hirsuties.多毛症女性的皮肤胶原蛋白和厚度
Br Med J. 1970 Dec 26;4(5738):772. doi: 10.1136/bmj.4.5738.772.
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[Androgens and bone metabolism. Significance in osteoporosis in man and woman].[雄激素与骨代谢。对男性和女性骨质疏松症的意义]
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Osteoporosis, a unitary hypothesis of collagen loss in skin and bone.骨质疏松症，一种关于皮肤和骨骼中胶原蛋白流失的单一假说。
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[Diagnosis and therapy of osteoporosis from the viewpoint of the gynecologist].从妇科医生角度看骨质疏松症的诊断与治疗
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7
Sex hormones and skin collagen content in postmenopausal women.绝经后女性的性激素与皮肤胶原蛋白含量
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[A potential of selective androgen receptor modulator(SARM)for the therapy of osteoporosis].选择性雄激素受体调节剂（SARM）治疗骨质疏松症的潜力
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Effect of Collagen Hydrolysates from Silver Carp Skin () on Osteoporosis in Chronologically Aged Mice: Increasing Bone Remodeling.胶原蛋白水解物（）对衰老小鼠骨质疏松症的影响：增加骨重塑。
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Effect of conventional and newer forms of treatment on calcium absorption in osteoporosis.传统及新型治疗方式对骨质疏松症患者钙吸收的影响
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Signaling circuits and the apical extracellular matrix in aging: connections identified in the nematode .衰老过程中的信号通路和顶端细胞外基质：在线虫中鉴定出的连接
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Skin chronological aging drives age-related bone loss via secretion of cystatin-A.皮肤自然老化通过胱抑素-A的分泌导致与年龄相关的骨质流失。
Nat Aging. 2022 Oct;2(10):906-922. doi: 10.1038/s43587-022-00285-x. Epub 2022 Oct 6.
4
Osteoporosis, like skin ageing, is caused by collagen loss which is reversible.骨质疏松症与皮肤老化一样，是由可逆转的胶原蛋白流失引起的。
J R Soc Med. 2020 Apr;113(4):158-160. doi: 10.1177/0141076820910315.
5
Correlation between skin and bone parameters in women with postmenopausal osteoporosis: A systematic review.绝经后骨质疏松症女性皮肤与骨骼参数的相关性：一项系统综述。
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Age and skin site related differences in steroid metabolism in male skin point to a key role of sebocytes in cutaneous hormone metabolism.男性皮肤中与年龄和皮肤部位相关的类固醇代谢差异表明，皮脂腺细胞在皮肤激素代谢中起关键作用。
Dermatoendocrinol. 2012 Jan 1;4(1):58-64. doi: 10.4161/derm.19201.
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Management of osteoporosis. An overview.骨质疏松症的管理。概述。
Drugs Aging. 1998;12 Suppl 1:25-32. doi: 10.2165/00002512-199812001-00004.
8
Impairment of granulation tissue formation after menopause.绝经后肉芽组织形成受损。
J Endocrinol Invest. 1996 Apr;19(4):215-8. doi: 10.1007/BF03349870.
9
Sex hormones and skin collagen content in postmenopausal women.绝经后女性的性激素与皮肤胶原蛋白含量
Br Med J (Clin Res Ed). 1983 Nov 5;287(6402):1337-8. doi: 10.1136/bmj.287.6402.1337.
10
Skin collagen and thickness in women with hirsuties.多毛症女性的皮肤胶原蛋白和厚度
Br Med J. 1970 Dec 26;4(5738):772. doi: 10.1136/bmj.4.5738.772.

本文引用的文献

1
Corticosteroid purpura.皮质类固醇性紫癜
Lancet. 1960 Jan 9;1(7115):93-4. doi: 10.1016/s0140-6736(60)92907-x.
2
SENILE DEGENERATION OF SKIN COLLAGEN.皮肤胶原蛋白的老年性退变
Clin Sci. 1963 Dec;25:487-91.
3
EFFECT OF ULTRA-VIOLET LIGHT ON SKIN COLLAGEN.紫外线对皮肤胶原蛋白的影响。
Nature. 1963 Jul 13;199:192-3. doi: 10.1038/199192a0.
4
The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.对含有少量这种亚氨基酸的组织和蛋白质样品中羟脯氨酸的测定。
Arch Biochem Biophys. 1961 May;93:440-7. doi: 10.1016/0003-9861(61)90291-0.
5
The response to adrenalectomy of a leucoerythroblastic process due to metastatic carcinoma of breast.因乳腺癌转移癌导致的白细胞红细胞增多症对肾上腺切除术的反应。
Lancet. 1961 Apr 1;1(7179):690-3. doi: 10.1016/s0140-6736(61)91721-4.
6
Quantitative changes in skin collagen in morphoea.硬斑病中皮肤胶原蛋白的定量变化。
Br J Dermatol. 1967 Aug-Sep;79(8):456-9. doi: 10.1111/j.1365-2133.1967.tb11533.x.
7
The effect of sex and site on the composition of skin in the rat and mouse.性别和部位对大鼠和小鼠皮肤成分的影响。
Biochem J. 1964 Aug;92(2):364-8. doi: 10.1042/bj0920364.
8
Skin collagen in osteogenesis imperfecta.成骨不全症中的皮肤胶原蛋白。
Lancet. 1970 Apr 25;1(7652):860-1. doi: 10.1016/s0140-6736(70)91689-2.

骨质疏松症、皮肤胶原蛋白与雄激素。

Osteoporosis, skin collagen, and androgen.

作者信息

Black M M, Shuster S, Bottoms E

出版信息

Br Med J. 1970 Dec 26;4(5738):773-4. doi: 10.1136/bmj.4.5738.773.

DOI:10.1136/bmj.4.5738.773
PMID:5503232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1820376/
Abstract

Total skin collagen was found to be decreased in untreated patients with osteoporosis, particularly women, but increased after treatment with androgens in women. Decreased body collagen may possibly be a primary defect in osteoporosis, while androgens may increase total skin collagen.

摘要

研究发现，未经治疗的骨质疏松症患者，尤其是女性，其皮肤总胶原蛋白含量降低，但女性接受雄激素治疗后该含量会增加。体内胶原蛋白减少可能是骨质疏松症的一个主要缺陷，而雄激素可能会增加皮肤总胶原蛋白含量。