Bianciotto Carlos G, Demirci Hakan Y, Shields Carol L, Shields Jerry A
Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Ophthalmic Plast Reconstr Surg. 2008 Jan-Feb;24(1):62-3. doi: 10.1097/IOP.0b013e3181607435.
A 56-year-old man had a 6-month history of a progressively enlarging mass of his right upper eyelid. Thirty-six years previously he had undergone thyroidectomy for medullary thyroid carcinoma in the absence of family history. Supraclavicular lymph node metastases were discovered 3 years after initial diagnosis, pulmonary metastasis 26 years later, and cervical lymph node metastases 35 years later. Ocular examination revealed a pedunculated, amelanotic, highly vascularized metastasis involving the right upper eyelid and palpebral conjunctiva. Ophthalmoscopy revealed 2 amelanotic, dome-shaped choroidal metastases in the right eye and 3 similar tumors in the left eye. Medullary thyroid carcinoma not associated with the multiple endocrine neoplasia syndromes can metastasize to the ocular region and metastases can occur decades after the original diagnosis.
一名56岁男性有右上眼睑肿物逐渐增大6个月的病史。36年前，他在无家族史的情况下因甲状腺髓样癌接受了甲状腺切除术。初诊3年后发现锁骨上淋巴结转移，26年后出现肺转移，35年后出现颈部淋巴结转移。眼部检查发现一个带蒂、无色素、血管丰富的转移瘤，累及右上眼睑和睑结膜。检眼镜检查发现右眼有2个无色素、圆顶状脉络膜转移瘤，左眼有3个类似肿瘤。不伴有多发性内分泌肿瘤综合征的甲状腺髓样癌可转移至眼部区域，转移可在原诊断数十年后发生。
