Mudhar Hardeep Singh, Nuruddin Murtuza, Roy Soma Rani
National Specialist Ophthalmic Pathology Service (NSOPS), Department of Histopathology, E-Floor, Royal Hallamshire Hospital, Sheffield, UK.
Chittagong Eye Infirmary and Training Complex, Chittagong, Bangladesh.
Ocul Oncol Pathol. 2016 Apr;2(3):156-9. doi: 10.1159/000442987. Epub 2015 Dec 19.
The aim of this study was to report the clinical and histopathological features of an eyelid metastasis in a 70-year-old male with no prior medical history.
A 70-year-male presented with a painless, hard, red nodular growth in his left lower medial eyelid of 6 months duration, involving the canaliculus and punctum. He did not complain of any other ocular or systemic abnormality. The clinical differential diagnosis included lymphoma or a primary adnexal tumour. The lesion was excised under local anaesthetic cover and sent for routine histopathological analysis.
The histology revealed a carcinoma involving the posterior and anterior lamella of the lower lid. It was composed of papillary and follicular areas. The tumour nuclei were optically clear, overlapping, had nuclear grooves and were associated with eosinophilic colloid material. The tumour cells were strongly positive for nuclear thyroid transcription factor-1 and thyroglobulin (which also stained some of the eosinophilic colloid material). The histological and immunohistochemical features were those of metastatic papillary carcinoma of the thyroid. Unfortunately, the patient's thyroid has yet to be examined because of loss to follow-up.
To the best of our knowledge, this is the first report of thyroid papillary carcinoma metastasizing to the eyelid as the presenting feature of the disease. A review of the literature of metastatic thyroid carcinoma to the eyelids is presented, to place the findings of this case report in context.
本研究旨在报告一名无既往病史的70岁男性眼睑转移瘤的临床和组织病理学特征。
一名70岁男性，其左下睑内侧出现一个无痛性、质地硬、红色结节状肿物，持续6个月，累及泪小管和泪点。他未诉说任何其他眼部或全身异常。临床鉴别诊断包括淋巴瘤或原发性附属器肿瘤。在局部麻醉下切除病变并送去进行常规组织病理学分析。
组织学检查显示癌累及下睑的前后层。它由乳头状和滤泡状区域组成。肿瘤细胞核光学透明、相互重叠，有核沟，并伴有嗜酸性胶体物质。肿瘤细胞甲状腺转录因子-1和甲状腺球蛋白呈强阳性（后者也使部分嗜酸性胶体物质染色）。组织学和免疫组化特征符合甲状腺转移性乳头状癌。遗憾的是，由于失访，患者的甲状腺尚未检查。
据我们所知，这是首例以眼睑转移为首发表现的甲状腺乳头状癌报告。本文对甲状腺癌转移至眼睑的文献进行了综述，以结合本病例报告的结果进行阐述。
