Kimber Marc C, Moody Christopher J
School of Chemistry, University of Nottingham, University Park, Nottingham, UK.
Chem Commun (Camb). 2008 Feb 7(5):591-3. doi: 10.1039/b715644h. Epub 2007 Nov 23.
A 20-membered macrocyclic thiodepsipeptide has been synthesized as a model for the southern hemisphere of nosiheptide, the key steps being assembly of an acyclic precursor by amide coupling of indole and thiazole fragments followed by formation of the thiolactone in the macrocyclization step.
已合成一种20元大环硫代缩肽作为诺西肽南半球的模型，关键步骤是通过吲哚和噻唑片段的酰胺偶联组装无环前体，然后在大环化步骤中形成硫内酯。
