Pearson Anthony J, Ciurea Diana V
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.
J Org Chem. 2008 Jan 18;73(2):760-3. doi: 10.1021/jo702245z. Epub 2007 Dec 23.
A tripeptido--arene--ruthenium complex was prepared as a key precursor for the projected synthesis of orienticin C, demonstrating that the cyclopentadienylruthenium moiety can be attached to a chloroarene in the presence of multiple functionality. The ruthenium-mediated intramolecular SNAr reaction for formation of the required diaryl ether linkage was successfully tested on a model system.
制备了一种三肽-芳烃-钌配合物，作为预期合成orienticin C的关键前体，证明了在存在多种官能团的情况下，环戊二烯基钌部分可以连接到氯芳烃上。在模型体系上成功测试了用于形成所需二芳基醚键的钌介导分子内亲核芳香取代反应。
