Somunkiran Asli, Coskun Abdurrahman, Demirci Fuat, Yucel Oguz
Department of Obstetrics and Gynecology, School of Medicine, Duzce University, Konuralp, Turkey.
Gynecol Endocrinol. 2008 Feb;24(2):79-83. doi: 10.1080/09513590701718307.
The aim of the present prospective controlled study was to examine the influence of 17beta-estradiol and tibolone on tumor necrosis factor-alpha (TNF-alpha) levels in healthy women with surgical menopause. Forty-five surgically menopausal women were included in the study. Thirty women were randomized to receive tibolone 2.5 mg or 17beta-estradiol 2 mg daily for 16 weeks. Fifteen surgically menopausal women who refused hormone therapy served as controls. Serum was collected from the subjects at baseline and at the end of the study for TNF-alpha assay. Neither tibolone nor 17beta-estradiol showed a significant influence on TNF-alpha level at the end of 16 weeks in comparison with baseline. Although tibolone induced a trend toward decreased level of TNF-alpha (3.30 +/- 0.42 vs. 2.56 +/- 1.94 microg/dl), this was non-significant. The slight increase observed in TNF-alpha level in the control group was also insignificant (3.60 +/- 1.20 vs. 4.10 +/- 0.70 microg/dl). Overall, these results demonstrate no significant effects of either tibolone or 17beta-estradiol on circulating TNF-alpha level in surgically menopausal women. However, the significant difference achieved between the tibolone and control group after treatment is promising and needs to be investigated in trials with longer treatment periods.
本前瞻性对照研究的目的是检测17β-雌二醇和替勃龙对手术绝经的健康女性肿瘤坏死因子-α（TNF-α）水平的影响。45名手术绝经女性纳入本研究。30名女性被随机分为两组，分别每日服用2.5mg替勃龙或2mg 17β-雌二醇，共16周。15名拒绝激素治疗的手术绝经女性作为对照组。在基线期和研究结束时采集受试者血清用于TNF-α检测。与基线相比，16周结束时，替勃龙和17β-雌二醇对TNF-α水平均未显示出显著影响。虽然替勃龙使TNF-α水平有下降趋势（3.30±0.42 vs. 2.56±1.94μg/dl），但无统计学意义。对照组中观察到的TNF-α水平的轻微升高也无统计学意义（3.60±1.20 vs. 4.10±0.70μg/dl）。总体而言，这些结果表明替勃龙和17β-雌二醇对手术绝经女性循环TNF-α水平均无显著影响。然而，治疗后替勃龙组与对照组之间出现的显著差异很有前景，需要在更长治疗期的试验中进行研究。
