Ichinose A, Fukunaga A, Terashi H, Nishigori C, Tanemura A, Nakajima T, Akishima-Fukasawa Y, Ishikawa Y, Ishii T
Department of Plastic Surgery, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan.
J Eur Acad Dermatol Venereol. 2008 Feb;22(2):168-73. doi: 10.1111/j.1468-3083.2007.02358.x.
Mondor's disease (MD) is considered an inflammatory condition of superficial vasculitis that develops mainly in the anterolateral thoracoabdominal wall. The pathogenesis of the disease has been controversial, however, because of the lack of histopathologic methods for differentiating between the small vein and the lymphatic vessel.
To objectively examine the origin of vascular lesions in MD, we investigated the endothelial cells of their blood and lymphatic vessels.
Immunohistochemical examinations were carried out on specimens involving vascular lesions from 16 patients with MD, using antibodies against von Willebrand factor and human lymphatic vessel endothelial hyaluronan receptor-1, which specifically discriminate between lymphatic and blood vessels.
The histopathologic findings clearly showed thrombophlebitis in 14 patients, a lesion originating in the lymphatic vessel in one patient, and sclerosis that consisted of the artery together with veins in another.
This study suggests that almost all cases of MD are due to thrombophlebitis, with a small minority due to lymphangitis or other conditions. We believe this study will contribute to the better recognition of the factual changes in the condition designated MD.
蒙多氏病（MD）被认为是一种主要发生在胸腹壁前外侧的浅表血管炎炎症性疾病。然而，由于缺乏区分小静脉和淋巴管的组织病理学方法，该病的发病机制一直存在争议。
为了客观地研究MD血管病变的起源，我们对其血管和淋巴管的内皮细胞进行了研究。
对16例MD患者的血管病变标本进行免疫组织化学检查，使用针对血管性血友病因子和人淋巴管内皮透明质酸受体-1的抗体，这两种抗体可特异性区分淋巴管和血管。
组织病理学结果清楚地显示，14例患者为血栓性静脉炎，1例患者病变起源于淋巴管，另1例患者为动脉和静脉共同硬化。
本研究表明，几乎所有MD病例均由血栓性静脉炎引起，少数病例由淋巴管炎或其他情况引起。我们相信这项研究将有助于更好地认识MD这种疾病的实际变化。
