Anderson G H
Department of Medicine, SUNY Health Science Center, Syracuse, New York, Slocum-Dickson Medical Group, New Hartford, New York, USA.
Saudi J Kidney Dis Transpl. 1999 Jul-Sep;10(3):286-97.
We evaluate in this study the factors associated with the effect of age on blood pressure in more than 4800 patients. Their physicians referred them to evaluate for secondary causes for their hypertension. Factors studied included history and physical examination, serum sodium, potassium and creatinine, a stimulated plasma renin and catecholamine. We also studied the blood pressure response to infusion of either saralasin (an angiotensin II analogue) or enalapril (an angiotensin converting enzyme inhibitor), and plasma aldosterone and cortisol after infusion of saline. We measured serum thyroxin and thyroid stimulating hormone concentrations on 1061 consecutive patients in this series. The results of our study show that increased age is associated with a significant increase in the prevalence of hypertension and especially of systolic hypertension after age 60 years. Increased obesity between age 30-50 years is associated with significant increases in diastolic blood pressure and this trend is also seen in African-Americans who are heavier than whites. Increased age is associated with an increased prevalence of secondary forms of hypertension including atherosclerotic renovascular hypertension, renal insufficiency and primary hypothyroidism.
在本研究中，我们评估了4800多名患者中与年龄对血压影响相关的因素。他们的医生将他们转诊以评估其高血压的继发原因。所研究的因素包括病史和体格检查、血清钠、钾和肌酐、刺激后的血浆肾素和儿茶酚胺。我们还研究了对注射沙拉新（一种血管紧张素II类似物）或依那普利（一种血管紧张素转换酶抑制剂）的血压反应，以及注射生理盐水后的血浆醛固酮和皮质醇。我们测量了该系列中1061例连续患者的血清甲状腺素和促甲状腺激素浓度。我们的研究结果表明，年龄增长与高血压患病率显著增加相关，尤其是60岁以后的收缩期高血压。30至50岁之间肥胖增加与舒张压显著升高相关，这种趋势在体重比白人重的非裔美国人中也可见。年龄增长与继发性高血压形式的患病率增加相关，包括动脉粥样硬化性肾血管性高血压、肾功能不全和原发性甲状腺功能减退。
