Asmare Deresse Sinamaw, Abebe Tadegew Adane, Miskir Mezgebu, Ashenef Baye, Adugna Adane, Muche Yalew, Melkamu Abateneh, Jemal Mohammed, Getinet Mamaru, Mengistu Enyew Fenta, Amare Gashaw Azanaw, Belew Habtamu, Tegegne Bantayehu Addis, Baylie Temesgen, Haimanot Aysheshim Belaineh
Department of Biomedical Science, School of Medicine, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Department of Surgery, School of Medicine, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia.
Sci Rep. 2025 Apr 10;15(1):12221. doi: 10.1038/s41598-025-97578-z.
Patients with diabetes had significant vascular resistance, which was explained by vascular remodeling and an increase in fluid volume as a result of hyperglycemia. Insulin resistance in type 2 diabetes impairs lipid catabolism, and obesity raises the risk of isolated systolic hypertension. However, in Ethiopia minimal study has been conducted to address the specific relationship between isolated systolic hypertension and type 2 diabetes. Therefore, this study aims to determine the magnitude and determinants of isolated systolic hypertension among type 2 diabetes patients in selected referral hospitals of Amhara region, Ethiopia. A multicenter institution-based cross-sectional study was conducted from September 1 and December 30, 2023. Referral hospitals were chosen using simple random sampling. Additionally, participants in the study were chosen from the designated referral hospitals using systematic sampling approaches. To collect clinical and sociodemographic data, an interviewer-administered questionnaire was utilized. Epi-data version-4.6 and Stata-14 were used for data entry and statistical analysis, respectively. The descriptive statistics were presented with tables and graphs. A binary logistic regression model was fitted to identify associated factors of isolated systolic hypertension. In the final model, statistical significance was decided at p ≤ 0.05, and the strength of association was indicated using an adjusted odds ratio with 95% CI. The analysis included 258 participants, and the prevalence of isolated systolic hypertension was found to be 21.3% (95% CI 18-27.1%). Older age (AOR = 4.64, 95%CI 1.31,16.36), fasting blood sugar of ≥ 130 mg/dl (AOR = 2.32, 95% CI; 1.04, 5.19), and BMI > 25 Kg/m (AOR = 2.75, 95% CI (1.33, 5.68)) were statistically significant factors of isolated systolic hypertension. The prevalence of isolated systolic hypertension (ISH) in this study was high, affecting large population of Type 2 Diabetes Mellitus (T2DM) patients. Older age, high body mass index (BMI), and elevated fasting blood sugar levels were identified as key determinants of ISH. The study emphasizes the need for regular monitoring and management of blood pressure in T2DM patients, particularly those who are older, and have higher BMI.
糖尿病患者存在显著的血管阻力，这可通过血管重塑以及高血糖导致的血容量增加来解释。2型糖尿病中的胰岛素抵抗会损害脂质分解代谢，而肥胖会增加单纯收缩期高血压的风险。然而，在埃塞俄比亚，针对单纯收缩期高血压与2型糖尿病之间的具体关系开展的研究极少。因此，本研究旨在确定埃塞俄比亚阿姆哈拉地区选定转诊医院中2型糖尿病患者单纯收缩期高血压的严重程度及其决定因素。2023年9月1日至12月30日进行了一项基于多中心机构的横断面研究。采用简单随机抽样选择转诊医院。此外，研究参与者是从指定的转诊医院使用系统抽样方法选取的。为收集临床和社会人口学数据，采用了访谈员管理的问卷。分别使用Epi - data 4.6版和Stata - 14进行数据录入和统计分析。描述性统计以表格和图表呈现。采用二元逻辑回归模型来确定单纯收缩期高血压的相关因素。在最终模型中，当p≤0.05时判定具有统计学意义，并使用调整后的比值比及95%置信区间来表示关联强度。该分析纳入了258名参与者，发现单纯收缩期高血压的患病率为21.3%（95%置信区间18 - 27.1%）。年龄较大（调整后的比值比=4.64，95%置信区间1.31,16.36）、空腹血糖≥130mg/dl（调整后的比值比=2.32，95%置信区间；1.04,5.19）以及体重指数>25 Kg/m（调整后的比值比=2.75，95%置信区间(1.33,5.68)）是单纯收缩期高血压的统计学显著因素。本研究中单纯收缩期高血压（ISH）的患病率较高，影响了大量的2型糖尿病（T2DM）患者。年龄较大、高体重指数（BMI）以及空腹血糖水平升高被确定为ISH的关键决定因素。该研究强调了对T2DM患者，尤其是年龄较大且BMI较高的患者进行定期血压监测和管理的必要性。
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