Hill S Y, Steinhauer S R, Smith T R, Locke J
Alcoholism and Genetics Research Program, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213.
J Subst Abuse. 1991;3(3):351-69. doi: 10.1016/s0899-3289(10)80018-5.
This review summarizes the efforts of our research program to identify markers for alcoholism risk, which broadly fall within the domain of temperament and those which may be described as attentional or information-processing capacities. Analyses of three-generation pedigrees that include minor children at higher risk of becoming alcoholic indicate that event-related potential characteristics differ between high- and low-risk children. Newer results concerning cardiac responsivity both in minor children and adult high-risk individuals are presented. These results suggest a relationship between personality or temperament on the one hand, and cardiac responsivity on the other. Additional neurobehavioral markers are addressed including static ataxia. Recent segregation analyses and linkage to particular DNA segments are also included.
本综述总结了我们研究项目为确定酒精成瘾风险标志物所做的努力，这些标志物大致属于气质范畴以及那些可被描述为注意力或信息处理能力的范畴。对包含有较高酒精成瘾风险的未成年子女的三代谱系进行分析表明，高风险和低风险儿童之间与事件相关的电位特征存在差异。文中还呈现了有关未成年儿童和成年高风险个体心脏反应性的最新研究结果。这些结果表明一方面个性或气质与另一方面心脏反应性之间存在关联。此外还探讨了包括静态共济失调在内的其他神经行为标志物。近期的分离分析以及与特定DNA片段的连锁分析也涵盖其中。
