Polich J, Pollock V E, Bloom F E
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.
Psychol Bull. 1994 Jan;115(1):55-73. doi: 10.1037/0033-2909.115.1.55.
The P3(00) event-related brain potential (ERP) is used to study the development of alcoholism by comparing males who have a positive family history of alcoholism with control Ss who have no such familial history. Meta-analysis indicated that overall, smaller P3 amplitudes were obtained from males with family histories of alcoholism compared to controls. Moderator analysis indicated that paradigms using difficult visual tasks yielded the most reliable effects. Furthermore, no differences in outcomes were obtained among studies that recruited positive family history Ss exclusively from among individuals whose father had received treatment for alcoholism as compared with other studies. These findings are discussed in the context of using ERPs as an evaluative tool in the study of psychopathology.
P3(00) 事件相关脑电位（ERP）被用于通过比较有酒精中毒家族史的男性与没有此类家族史的对照受试者来研究酒精中毒的发展。元分析表明，总体而言，与对照组相比，有酒精中毒家族史的男性获得的P3波幅较小。调节分析表明，使用困难视觉任务的范式产生的效应最可靠。此外，与其他研究相比，仅从其父亲接受过酒精中毒治疗的个体中招募有阳性家族史受试者的研究在结果上没有差异。这些发现是在将ERP用作精神病理学研究中的评估工具的背景下进行讨论的。
