Jancula Daniel, Drábková Michaela, Cerný Jirí, Karásková Marie, Korínková Radka, Rakusan Jan, Marsálek Blahoslav
Centre for Cyanobacteria and Their Toxins, Institute of Botany, Academy of Sciences of the Czech Republic, Kvetná 8, 60365 Brno, Czech Republic.
Environ Toxicol. 2008 Apr;23(2):218-23. doi: 10.1002/tox.20324.
Phthalocyanines and their analogues show great potential as photodynamic agents producing reactive oxygen species (ROS), especially in medicine. However, their biocidal effects may also be employed to inhibit various undesirable organisms. This study explores their potential algicidal effects. The laboratory tests concern the effects of various phthalocyanine derivatives on the green alga Pseudokirchneriella subcapitata and cyanobacterium Synechococcus nidulans. Their effects on one example of the sensitive nontarget aquatic organism-crustacean Daphnia magna were also screened. Among 31 tested compounds, the cationic phthalocyanines substituted with heterocycle exhibited the strongest effects on phytoplankton species, some of them even below the level of 1 mg/L, while effects on crustaceans ranged from 3.6 to more than 50 mg/L. These results show that some phthalocyanine derivatives can act as potent algicides.
酞菁及其类似物作为产生活性氧（ROS）的光动力剂具有巨大潜力，尤其是在医学领域。然而，它们的杀菌作用也可用于抑制各种有害生物。本研究探讨了它们潜在的杀藻作用。实验室测试关注各种酞菁衍生物对绿藻小形伪蹄形藻和蓝藻巢状集胞藻的影响。还筛选了它们对敏感非靶标水生生物——甲壳动物大型溞的影响。在31种测试化合物中，用杂环取代的阳离子酞菁对浮游植物物种的影响最强，其中一些甚至低于1 mg/L的水平，而对甲壳动物的影响范围为3.6至超过50 mg/L。这些结果表明，一些酞菁衍生物可作为有效的杀藻剂。
