血细胞比容值和氧分压对灌注肝脏氧化还原状态及代谢的影响。
Effect of haematocrit value and pO2 on the redox state and metabolism of the perfused liver.
作者信息
Mayes P A, Felts J M
出版信息
Biochem J. 1976 Jun 15;156(3):685-9. doi: 10.1042/bj1560685.
Abstract
- The haematocrit value and pO2 of blood perfusing the isolated liver were varied. Provided O2 content of the blood was not rate-limiting, O2 consumption was related to haemotocrit value rather than O2 saturation or pO2. 2. Hypoxia caused the blood-glucose concentration and ketogenesis to increase and the output of very-low-density (d less than 1.006) lipoproteins to decrease. 3. A decrease in pO2 caused an increase in both the (lactate)/(pyruvate) and (3-hydroxybutyrate)/(acetoacetate) and a decrease in (ATP)/(ADP) ratios, independently of O2 consumption. 4. The more reduced redox state was associated with a shift in the balance between the oxidation and esterification of free fatty acids in favour of oxidation. 5. Acetoacetate may be an important hydrogen acceptor during hypoxia of the liver.
摘要
- 灌注离体肝脏的血液的血细胞比容值和氧分压发生了变化。如果血液中的氧含量不是限速因素，那么氧消耗与血细胞比容值相关，而不是与氧饱和度或氧分压相关。2. 缺氧导致血糖浓度和生酮作用增加，极低密度（密度小于1.006）脂蛋白的输出减少。3. 氧分压降低导致（乳酸）/（丙酮酸）和（3-羟基丁酸）/（乙酰乙酸）升高，以及（三磷酸腺苷）/（二磷酸腺苷）比值降低，且与氧消耗无关。4. 氧化还原状态越低，游离脂肪酸氧化与酯化之间的平衡越偏向氧化。5. 在肝脏缺氧期间，乙酰乙酸可能是重要的氢受体。
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本文引用的文献
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