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沙特阿拉伯儿童春季角结膜炎的管理

Management of vernal keratoconjunctivitis in children in Saudi Arabia.

作者信息

AlHarkan Dora Hamad

机构信息

Department of Ophthalmology, Medical College, Qassim University, Qassim, Saudi Arabia.

出版信息

Oman J Ophthalmol. 2020 Feb 17;13(1):3-12. doi: 10.4103/ojo.OJO_263_2018. eCollection 2020 Jan-Apr.

Abstract

Vernal keratoconjunctivitis is a chronic inflammatory disease of the ocular surface and one of the worst types of allergic conjunctival diseases. Because of its chronic nature, it can damage the cornea, resulting in sight-threatening complications if left untreated. The disease affects mainly young children starting around the age of 7 years. We used keywords to search for published English articles in PUBMED, Google Scholar, EMBASE, and Cochrane Database of Systematic Reviews. Most of the published literature is focusing on general management of the disease and few publications focusing on treatment in the pediatric age group. We highlight the importance of how is the topical management differs between age groups. We focused on the importance of doing cycloplegic refraction for each child as the risk of keratoconus and oblique astigmatism is high in these cases. Furthermore, we highlight the importance of using eye lubricants as a therapeutic and preventive tool for the attacks of the disease. We highlight that most of the recent effective medications (especially the off-label ones) are not available in Saudi Arabia, such as tacrolimus, and some are only available to be prepared in tertiary center pharmacies as Cyclosporine A with higher concentrations.

摘要

春季角结膜炎是一种眼表慢性炎症性疾病,也是最严重的变应性结膜疾病之一。因其具有慢性特点,如果不治疗,它会损害角膜,导致威胁视力的并发症。该疾病主要影响7岁左右开始发病的儿童。我们使用关键词在PubMed、谷歌学术、EMBASE和Cochrane系统评价数据库中搜索已发表的英文文章。大多数已发表的文献聚焦于该疾病的一般管理,而很少有文献关注儿科年龄组的治疗。我们强调了不同年龄组局部治疗差异的重要性。我们关注到对每个儿童进行睫状肌麻痹验光的重要性,因为这些病例中圆锥角膜和斜散光的风险很高。此外,我们强调了使用眼部润滑剂作为该疾病发作的治疗和预防工具的重要性。我们强调最近的大多数有效药物(尤其是未按药品说明书用药的药物)在沙特阿拉伯无法获得,如他克莫司,有些药物仅在三级中心药房才能配制高浓度的环孢素A。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ef0/7050462/d84bca04baf3/OJO-13-3-g001.jpg

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