Marazziti D, Conti L
Psychiatric Clinic, University of Pisa, Italy.
Eur Neuropsychopharmacol. 1991 May;1(2):169-72. doi: 10.1016/0924-977x(91)90719-b.
The similarities between blood platelets and serotonin (5HT) neurons offer a reliable tool of exploring 5HT system. The aim of our study was to evaluate platelet [3H]imipramine binding in suicide attempters, as compared with depressed patients and healthy controls. In addition, we measured aggressive features in the 3 groups, by a standardized rating scale, the Inventory for assessing different kinds of ostility (QTA). The results showed a significant decrease in the maximum binding capacity (Bmax) of 3H-imipramine binding to platelet membranes in suicide attempters, who also exhibited higher total and single item scores at QTA than healthy controls or depressed patients. Both biological and psychological findings are suggestive of an aggression dysregulation in suicide attempters.
血小板与血清素（5-羟色胺，5HT）神经元之间的相似性为探索5HT系统提供了一个可靠的工具。我们研究的目的是评估自杀未遂者血小板[3H]丙咪嗪结合情况，并与抑郁症患者和健康对照者进行比较。此外，我们通过标准化评分量表——评估不同类型敌意的量表（QTA），测量了三组人群的攻击特征。结果显示，自杀未遂者血小板膜上3H-丙咪嗪结合的最大结合容量（Bmax）显著降低，而且他们在QTA上的总分和单项得分也高于健康对照者或抑郁症患者。生物学和心理学研究结果均提示自杀未遂者存在攻击调节障碍。
