荧光-磁性混合纳米结构：制备、性质及其在生物学中的应用

Fluorescent-magnetic hybrid nanostructures: preparation, properties, and applications in biology.

作者信息

Quarta Alessandra, Di Corato Riccardo, Manna Liberato, Ragusa Andrea, Pellegrino Teresa

机构信息

NNL-Nanotechnology Laboratory of CNR-INFM, Unità di ricerca IIT and Scuola Superiore ISUFI, 73100 Lecce, Italy.

出版信息

IEEE Trans Nanobioscience. 2007 Dec;6(4):298-308. doi: 10.1109/tnb.2007.908989.

DOI:10.1109/tnb.2007.908989

PMID:18217623

Abstract

Research on nanocomposite materials aims at developing nanoscale composites with innovative optical, chemical, and magnetic properties, all combined in one single nanostructure. In this scenario, nanostructures which show simultaneously fluorescent and magnetic features are of particular interest for pharmaceutical and biomedical applications. In this review, we will focus our attention on magnetic-fluorescent nanocomposite based on colloidal iron oxide nanocrystals combined with different classes of fluorophores which can be either organic dyes, such as fluoresceins, cyanines, porphyrins, or colloidal quantum dots. We will give an overview of the preparation methods of the magnetic-fluorescent nanocomposites that are now available and we will outline the most significant in vitro studies of such nanocomposites on living cells. Some examples of their applications in biology and medicine will also be discussed.

摘要

纳米复合材料的研究旨在开发具有创新光学、化学和磁性特性的纳米级复合材料，所有这些特性都结合在一个单一的纳米结构中。在这种情况下，同时具有荧光和磁性特征的纳米结构在制药和生物医学应用中特别受关注。在这篇综述中，我们将把注意力集中在基于胶体氧化铁纳米晶体与不同种类荧光团（可以是有机染料，如荧光素、花青、卟啉，或胶体量子点）结合的磁性荧光纳米复合材料上。我们将概述现有的磁性荧光纳米复合材料的制备方法，并概述此类纳米复合材料对活细胞进行的最重要的体外研究。还将讨论它们在生物学和医学中的一些应用实例。