Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul 120-749, Republic of Korea.
J Colloid Interface Sci. 2009 Dec 15;340(2):176-81. doi: 10.1016/j.jcis.2009.08.015. Epub 2009 Aug 15.
Novel bifunctional fluorescent magneto polymeric nanoprobes (FMPNs) were synthesized to provide simultaneous diagnostic information via magnetic resonance imaging (MRI) and optical imaging. FMPNs consist of ultra-sensitive magnetic nanocrystals that function as MR probes combined with Nile Red, which functions as a fluorescent probe. FMPNs were encapsulated by a nano-emulsion method in polyvinyl alcohol (PVA, 87-89% hydrolyzed) through a matrix of polymethyl methacrylate (PMMA). FMPNs exhibited excellent colloidal stability and monodispersity. The production of MR and optical images demonstrated that FMPNs have potential as dual-mode imaging agents.
新型双功能荧光磁聚合物纳米探针 (FMPNs) 被合成，以通过磁共振成像 (MRI) 和光学成像提供同时的诊断信息。FMPNs 由超灵敏的磁性纳米晶体组成，用作磁共振探针，与尼罗红结合，用作荧光探针。FMPNs 通过纳米乳液法用聚甲基丙烯酸甲酯 (PMMA) 基质包封在聚乙烯醇 (PVA，87-89%水解) 中。FMPNs 表现出优异的胶体稳定性和单分散性。MR 和光学图像的产生表明 FMPNs 具有作为双模成像剂的潜力。
