Burgos Patricia Miranda, Rasmusson Lars, Meirelles Luiz, Sennerby Lars
Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
Clin Implant Dent Relat Res. 2008 Sep;10(3):181-90. doi: 10.1111/j.1708-8208.2007.00074.x. Epub 2008 Jan 24.
Previous studies have shown the formation of more bone contacts with a moderately rough and porous titanium surface, created by anodic oxidation, as compared with nonmodified turned titanium control surfaces. The mechanisms leading to a stronger bone response to oxidized titanium are not well understood.
The aim of the study was to describe the early events of bone integration of titanium implants with oxidized and turned surfaces.
Nine adult New Zealand White rabbits and 18 implants were used in the study. One oxidized and one turned threaded titanium implants, which had been placed in the right tibial metaphysis, were analyzed in the present study. The implants were retrieved after 7, 14, and 28 days for light microscopic examination and histomorphometric measurements in ground sections.
Integration of oxidized implants was seen to occur as direct bone formation on the surface, while the integration of turned implants was a result of bone ingrowth from preexisting bone and bone marrow. For oxidized implants, an almost acellular, darkly stained layer was seen after 7 to 14 days, which later became populated with osteoblasts. The presence of osteoid seams indicated appositional bone growth from the substrate toward the surrounding tissues. The bone contact values were higher for oxidized implants, and the bone area values were higher for turned implants.
The present study confirms the idea that implant surface modification alters the bone tissue response to titanium. The early bone formation following surgery occurs directly on the moderately rough oxidized surface, while turned titanium surfaces are integrated by the ingrowth of bone from the adjacent bone marrow and preexisting bone tissues.
先前的研究表明，与未改性的车削钛对照表面相比，通过阳极氧化产生的中等粗糙度和多孔性的钛表面能形成更多的骨接触。导致对氧化钛有更强骨反应的机制尚不清楚。
本研究的目的是描述具有氧化表面和车削表面的钛植入物骨整合的早期事件。
本研究使用了9只成年新西兰白兔和18枚植入物。本研究分析了分别植入右胫骨近端干骺端的一枚氧化螺纹钛植入物和一枚车削螺纹钛植入物。在7天、14天和28天后取出植入物，进行光镜检查和磨片的组织形态计量学测量。
氧化植入物的整合表现为表面直接形成骨，而车削植入物的整合是已有骨和骨髓长入骨的结果。对于氧化植入物，在7至14天后可见一层几乎无细胞、染色深的层，随后有成骨细胞聚集。类骨质缝的存在表明从基质向周围组织的贴壁骨生长。氧化植入物的骨接触值较高，车削植入物的骨面积值较高。
本研究证实了植入物表面改性会改变骨组织对钛的反应这一观点。术后早期骨形成直接发生在中等粗糙度的氧化表面上，而车削钛表面则通过相邻骨髓和已有骨组织的骨长入实现整合。
