热处理对改善 Ti6Al4V 牙科种植体骨整合的影响：兔模型的组织学和组织形态计量学研究。
Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model.
机构信息
Department of Medical, Oral and Biotechnological Sciences and CeSi-MeT, University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
出版信息
Biomed Res Int. 2018 Jun 27;2018:2349698. doi: 10.1155/2018/2349698. eCollection 2018.
BACKGROUND
Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants.
PURPOSE
The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response .
METHODS
Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically .
RESULTS
A statistically significant difference ( = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at ≤ 0.05.
CONCLUSIONS
The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.
背景
纯钛仍然是牙科植入物的首选材料，其生物相容性和物理力学特性均符合金标准，而钛合金（Ti6Al4V）则具有良好的机械性能。钛氧化物层表面结构的形成会影响和改善牙科植入物周围的骨反应。
目的
本研究旨在评估 Ti6Al4V 种植体表面热疗对骨愈合反应的影响。
方法
将 16 个具有相同设计的植入物插入到股骨远端干骺端。将一个螺丝（长 13 毫米，直径 4 毫米）插入植入物床中。每只兔子接受两个植入物，一个植入左侧股骨，一个植入右侧股骨。对样本进行组织学评估。
结果
通过单向方差分析（ANOVA），实验组（BIC=69.25±4.49%）和对照组（BIC=56.25±4.8%）的骨-种植体接触百分比（BIC）在组织学上存在显著差异（=0.000034）。显著性水平设定为≤0.05。
结论
本研究结果表明，这是一种改善钛种植体周围骨愈合的新方法。
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