Korte M R, van Heerde M J, de Man R A, Betjes M H G
Department of Nephrology, Erasmus Medical Centre, Rotterdam, the Netherlands.
Neth J Med. 2008 Jan;66(1):27-30.
Mixed-type cryoglobulins are strongly associated with hepatitis C virus (HCV) infection and may lead to vasculitis with renal involvement. The treatment of this condition is antiviral therapy for HCV, but this may be ineffective or not tolerated because of side effects. Alternative strategies such as immunosuppressive drugs and plasmapheresis are of limited use, especially in patients after liver transplantation (LTx). We describe an LTx patient with cryoglobulinaemia-associated glomerulonephritis, who was treated successfully with the B cell depleting monoclonal antibody rituximab.
混合型冷球蛋白血症与丙型肝炎病毒（HCV）感染密切相关，可能导致累及肾脏的血管炎。这种病症的治疗方法是针对HCV的抗病毒治疗，但由于副作用，这种治疗可能无效或无法耐受。免疫抑制药物和血浆置换等替代策略的作用有限，尤其是在肝移植（LTx）后的患者中。我们描述了一名患有冷球蛋白血症相关肾小球肾炎的LTx患者，他通过B细胞耗竭单克隆抗体利妥昔单抗成功治愈。
