Demey Ignacio, Zimerman Máximo, Allegri Ricardo F, Serrano Cecilia M, Taragano Fernando E
Laboratorio de Investigación de la Memoria, Hospital Abel Zubizarreta, (GCBA).
Vertex. 2007 Jul-Aug;18(74):252-7.
The mild cognitive impairment (MCI), has emerged as an identifiable condition and in many cases is an intermediate state preceding diagnosable Alzheimer disease (AD) characterized by acquired cognitive deficits, without significant decline in functional activities of daily living. The aim of this study was to determine both the presence and type of neuropsychiatric manifestations in MCI patients and to compare them with both those suffering from mild AD and normal controls.
86 subjects were assessed, 27 were classified as having MCI, 39 as having presumable mild AD, and 20 normal controls matched by age and education. The Neuropsychiatric inventory (NPI-Q) was used to assess the neuropsychiatric manifestations.
The most common symptoms in the MCI group were irritability (55%), dysphoria (44%), apathy (37%), and anxiety (37%). Statistically significant differences were observed between the MCI and control groups regarding the above mentioned symptoms (p0.05). However, the differences between the MCI and mild AD groups were not found to be statistically significant.
MCI is associated with a high rate of neuropsychiatric symptoms (irritability, depression, anxiety and apathy). These symptoms have serious adverse consequences and should be considered in diagnosis criteria.
轻度认知障碍（MCI）已成为一种可识别的病症，在许多情况下是可诊断的阿尔茨海默病（AD）之前的中间状态，其特征为获得性认知缺陷，而日常生活功能活动无显著下降。本研究的目的是确定MCI患者神经精神症状的存在情况和类型，并将其与轻度AD患者及正常对照进行比较。
评估了86名受试者，其中27名被归类为患有MCI，39名被归类为可能患有轻度AD，20名正常对照在年龄和教育程度上相匹配。使用神经精神科问卷（NPI-Q）评估神经精神症状。
MCI组最常见的症状为易激惹（55%）、烦躁不安（44%）、淡漠（37%）和焦虑（37%）。在上述症状方面，MCI组与对照组之间存在统计学显著差异（p0.05）。然而，未发现MCI组与轻度AD组之间的差异具有统计学意义。
MCI与高比例的神经精神症状（易激惹、抑郁、焦虑和淡漠）相关。这些症状具有严重的不良后果，应在诊断标准中予以考虑。
