睡眠质量独立影响韩国类风湿关节炎女性患者的健康相关生活质量和认知功能：一项病例对照研究。
Sleep Quality Independently Affects Health-related Quality of Life and Cognitive Function in Korean Female Patients with Rheumatoid Arthritis: a Case-control Study.
机构信息
Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Division of Rheumatology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
出版信息
J Korean Med Sci. 2018 Jun 27;33(35):e216. doi: 10.3346/jkms.2018.33.e216. eCollection 2018 Aug 27.
BACKGROUND
This study aimed to address sleep quality in patients with rheumatoid arthritis (RA) and to determine how it affects health-related quality of life (HRQoL) and cognitive function.
METHODS
One hundred and twenty-three patients with RA and 76 healthy controls were enrolled in this study. Sleep quality was assessed using the Korean version of the Pittsburgh Sleep Quality Index (PSQI). Cognitive function and HRQoL was evaluated by a Korean-Montreal Cognitive Assessment (MoCA-K) and 36-item Short-Form Health Survey (SF-36), respectively. Other clinical, demographic, and laboratory data were obtained from retrospective medical chart review.
RESULTS
More patients in the RA group reported poor sleep quality (PSQI > 5) than in the control group (61% [75/123] vs. 39.5% [30/76]; = 0.003). Total PSQI was also significantly higher in the RA group (median [interquartile range], 7 [5-11] vs. 5 [3-6.75]; = 0.001). Total PSQI score negatively correlated with MoCA-K score (Spearman's rho () = -0.223; = 0.003) with a physical component summary (PCS) of SF-36 ( = -0.221; = 0.003) and a mental component summary (MCS) of SF-36 ( = -0.341; < 0.001), which means that poor sleep quality was associated with poor cognitive function and low HRQoL.
CONCLUSION
The findings of this study suggest that poor sleep quality is an independent risk factor for low HRQoL and cognitive dysfunction. Efforts to improve the sleep quality of RA patients seem to be an important aspect of integrative treatment for RA.
背景
本研究旨在探讨类风湿关节炎（RA）患者的睡眠质量，并确定其对健康相关生活质量（HRQoL）和认知功能的影响。
方法
本研究纳入了 123 例 RA 患者和 76 名健康对照者。使用匹兹堡睡眠质量指数（PSQI）的韩语版评估睡眠质量。使用韩国蒙特利尔认知评估（MoCA-K）和 36 项简短健康调查（SF-36）分别评估认知功能和 HRQoL。通过回顾性病历审查获取其他临床、人口统计学和实验室数据。
结果
与对照组（61%[75/123]比 39.5%[30/76]； = 0.003）相比，RA 组有更多的患者报告睡眠质量差（PSQI>5）。RA 组的 PSQI 总分也显著升高（中位数[四分位数间距]，7[5-11]比 5[3-6.75]； = 0.001）。PSQI 总分与 MoCA-K 评分呈负相关（Spearman's rho()=−0.223； = 0.003），与 SF-36 的生理成分综合评分（PCS）（ = −0.221； = 0.003）和心理成分综合评分（MCS）（ = −0.341； < 0.001）呈负相关，这意味着睡眠质量差与认知功能差和 HRQoL 低有关。
结论
本研究结果表明，睡眠质量差是 HRQoL 和认知功能障碍的独立危险因素。改善 RA 患者睡眠质量的努力似乎是 RA 综合治疗的一个重要方面。
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