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有前景的抗结核药物。

Promising drugs against tuberculosis.

作者信息

de Souza Marcus Vinícius Nora

机构信息

Instituto de Tecnologia em Fármacos-Far-Manguinhos. Rua Sizenando Nabuco 100, Manguinhos, 21041-250 Rio de Janeiro-RJ, Brazil.

出版信息

Recent Pat Antiinfect Drug Discov. 2006 Jan;1(1):33-44. doi: 10.2174/157489106775244163.

Abstract

Tuberculosis (TB) is an important public health problem worldwide due to AIDS epidemic, the advent of multidrug resistant strains (MDR) and the lack of new drugs in the market. TB is responsible for almost 3 millions deaths each year. According to WHO (World Health Organization), which declared tuberculosis a global health emergency in 1993, tuberculosis, without a coordinated control effort, will infect an estimated 1 billion people by 2020, killing 70 million. In spite of this problem, there is a lack of development of new TB drugs. For example, it has been nearly 35 years since the introduction of a new class of compounds for the treatment of TB. Thus, there is an urgent need for new drugs to fight against this disease. Considering that, this review aims promising drug candidates that are in development against TB.

摘要

由于艾滋病的流行、多重耐药菌株(MDR)的出现以及市场上缺乏新药,结核病(TB)是全球一个重要的公共卫生问题。结核病每年导致近300万人死亡。世界卫生组织(WHO)于1993年宣布结核病为全球卫生紧急情况,称如果没有协调一致的控制措施,到2020年结核病预计将感染10亿人,导致7000万人死亡。尽管存在这个问题,但新型结核病药物的研发却很匮乏。例如,自引入用于治疗结核病的新型化合物类别以来,已经过去了近35年。因此,迫切需要新药来对抗这种疾病。考虑到这一点,本综述旨在介绍正在研发的有前景的抗结核候选药物。

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