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西班牙慢性阻塞性肺疾病(COPD)的治疗有变化吗?一项社区多中心研究(VICE)的结果

[Has the treatment of COPD changed in Spain? Results of a community multicenter study (VICE)].

作者信息

Izquierdo Alonso J L, Rodríguez González-Moro J M, de Lucas Ramos P, Martín Centeno A, Gobartt Vázquez E

机构信息

Sección de Neumología, Hospital General Universitario de Guadalajara, Guadalajara, Spain.

出版信息

Rev Clin Esp. 2008 Jan;208(1):18-25. doi: 10.1157/13115003.

Abstract

INTRODUCTION

Many Clinical Practical Guides (CPG) that have specifically focused on the diagnosis and treatment of chronic obstructive pulmonary disease (COPD) have been elaborated over the last 5 years. However, their grade of application and effectiveness have not been verified.

METHOD

In order to evaluate if the diagnosis and treatment of COPD have been modified in our setting since their publication, a comparative analysis was proposed between the results of the IDENTEPOC study (n = 898) conducted in the year 2000 and the VICE study (n = 10,782), whose data were collected in 2005.

RESULTS

In the year 2000, 38.6% of the patients in primary health care were initially diagnosed of COPD using clinical and/or radiological criteria, with no functional confirmation versus 10.2% in the pneumology setting (p < 0.001). In 2005, 31% of the subjects had been diagnosed of COPD using spirometry in primary health care and 14% in pneumology did not show an obstructive pattern. In 2005, only 4.1% of the patients were receiving specific treatment for their smoking habit and the establishment of rehabilitation programs was not very relevant. No large differences in drug treatments were observed between both studies. The main difference in 2005 was a wide use of tiotropium and of combinations of beta2 agonists with inhaled corticosteroids. Although a mild escalation of treatment based on seriousness is observed in both series, the prescription guidelines do not adjust to the criteria established by the regulations.

CONCLUSIONS

The results of this analysis indicate that although the CPGs may be useful tools to improve the clinical management of COPD, the absence of relevant qualitative changes in the management of COPD after their publication suggests that their impact in the clinical practice is currently irrelevant.

摘要

引言

在过去5年里,已经制定了许多专门针对慢性阻塞性肺疾病(COPD)诊断和治疗的临床实践指南(CPG)。然而,它们的应用程度和有效性尚未得到验证。

方法

为了评估自COPD诊断和治疗指南发布以来,我们机构的相关情况是否有所改变,对2000年进行的IDENTEPOC研究(n = 898)和2005年收集数据的VICE研究(n = 10,782)的结果进行了对比分析。

结果

2000年,初级医疗保健机构中38.6%的患者最初根据临床和/或放射学标准被诊断为COPD,但未进行功能确认,而在肺病科这一比例为10.2%(p < 0.001)。2005年,初级医疗保健机构中31%的受试者通过肺功能测定被诊断为COPD,肺病科有14%的患者未表现出阻塞性模式。2005年,只有4.1%的患者因吸烟习惯接受了特定治疗,康复计划的制定也不太普遍。两项研究在药物治疗方面未观察到显著差异。2005年的主要差异在于噻托溴铵以及β2受体激动剂与吸入性糖皮质激素联合用药的广泛使用。尽管两个系列中基于病情严重程度的治疗都有轻微升级,但处方指南并未符合法规制定的标准。

结论

该分析结果表明,尽管临床实践指南可能是改善COPD临床管理的有用工具,但指南发布后COPD管理方面缺乏相关定性变化,这表明它们目前对临床实践的影响不大。

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