Wagner K R, Mei L, Huganir R L
Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Curr Opin Neurobiol. 1991 Jun;1(1):65-73. doi: 10.1016/0959-4388(91)90011-u.
Evidence in the past year has provided support for a prominent role of tyrosine phosphorylation in the regulation of neuronal function. The discovery that many novel forms of protein tyrosine kinases and phosphatases are expressed in the brain has revealed that the regulation of tyrosine phosphorylation is highly complex. The recent identification of substrate proteins in the brain for the protein tyrosine kinases and phosphatases has begun to clarify the functional role of tyrosine phosphorylation in the development and modulation of the nervous system.
过去一年的证据支持了酪氨酸磷酸化在神经元功能调节中起重要作用的观点。许多新型蛋白酪氨酸激酶和磷酸酶在大脑中表达这一发现表明，酪氨酸磷酸化的调节非常复杂。最近在大脑中鉴定出蛋白酪氨酸激酶和磷酸酶的底物蛋白，这已开始阐明酪氨酸磷酸化在神经系统发育和调节中的功能作用。
