Bagán José V, Murillo Judith, Poveda Rafael, Gavaldá Carmen, Jiménez Yolanda, Scully Crispian
Valencia University, Chairman Service of Stomatology, University General Hospital, C/Jativa 6 pta. 9, Valencia 46002, Spain.
Oral Oncol. 2004 Apr;40(4):440-3. doi: 10.1016/j.oraloncology.2003.10.008.
Proliferative verrucous leukoplakia (PVL) is an uncommon entity with a high tendency to develop oral squamous cell carcinomas (OSCCs). The objective of this study was to analyse the presence of various OSCCs in the same patient with PVL. We studied 19 patients with PVL who had developed at least one OSCC. We analysed how many of these developed more than one OSCC over a period between 24 and a maximum of 130 months, indicating the location of their OSCC, clinical type and the time lapse between the appearance of each of the different OSCCs in the same patient. Of the 19 patients, 10 presented more than one of these cancers, one of whom even went on to develop five different cancers. The most frequent location of OSCC was the gingiva and the palate; the least common was the tongue/floor of mouth. Ninety percent were women and 20% were smokers. The average time elapsed between the detection of the first tumour and the appearance of the second was 19.20 months (SD 13.41). Our patients with PVL developed a high frequency of OSCCs, on many occasions manifesting several cancers at different oral locations, thus demonstrating the field cancerization of this entity. The OSCC in PVL patients were at sites quite uncommonly affected in patients who develop OSCC in the absence of PVL.
增殖性疣状白斑（PVL）是一种罕见的疾病，具有很高的发展为口腔鳞状细胞癌（OSCC）的倾向。本研究的目的是分析同一例PVL患者中各种OSCC的存在情况。我们研究了19例已发展为至少1例OSCC的PVL患者。我们分析了其中有多少患者在24个月至最长130个月的时间段内发展为不止1例OSCC，指出其OSCC的位置、临床类型以及同一患者中各不同OSCC出现之间的时间间隔。在这19例患者中，10例出现了不止1种此类癌症，其中1例甚至发展为5种不同的癌症。OSCC最常见的部位是牙龈和腭部；最不常见的是舌部/口底。90%为女性，20%为吸烟者。从检测到第一个肿瘤到第二个肿瘤出现的平均时间为19.20个月（标准差13.41）。我们的PVL患者发生OSCC的频率很高，很多情况下在口腔不同部位出现多种癌症，从而证明了该疾病的场癌化现象。PVL患者的OSCC发生部位在无PVL的OSCC患者中相当少见。
