白细胞介素-18 -607 A/C基因多态性杂合性与结直肠癌风险相关。
Heterozygosity for interleukin-18 -607 A/C polymorphism is associated with risk for colorectal cancer.
作者信息
Nikiteas Nikolaos, Yannopoulos Athanasios, Chatzitheofylaktou Agapi, Tsigris Christos
机构信息
First Department of Surgery, University of Athens Medical School, Laikon General Hospital, Athens, Greece.
出版信息
Anticancer Res. 2007 Nov-Dec;27(6B):3849-53.
BACKGROUND
The possible contribution of interleukin-18 (IL-18) -607 A/C polymorphism towards the development of colorectal cancer was investigated.
PATIENTS AND METHODS
DNA samples of 84 patients with colorectal cancer (adenocarcinomas) and 89 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis. The resulting allele and genotype frequencies of patients were compared to those of the respective controls using Fischer's exact test and odds ratios.
RESULTS
The proportion of heterozygotes in the patient group was significantly higher than that in healthy controls (p < 0.01). This significant increase was detected independently of Dukes' tumor stage. Additionally, the carrier frequency of the mutant A allele was significantly higher in the patient group compared to controls (p < 0.05).
CONCLUSION
The results indicate that heterozygotes for the IL-18 -607 A/C polymorphism exhibit increased risk for colorectal cancer development.
背景
研究了白细胞介素-18（IL-18）-607 A/C多态性对结直肠癌发生发展的可能影响。
患者与方法
采用等位基因特异性聚合酶链反应及电泳分析，检测84例结直肠癌（腺癌）患者和89例健康对照者的DNA样本。使用费舍尔精确检验和比值比，将患者的等位基因和基因型频率与相应对照组进行比较。
结果
患者组杂合子比例显著高于健康对照组（p < 0.01）。这一显著增加与杜克肿瘤分期无关。此外，患者组中突变A等位基因的携带频率显著高于对照组（p < 0.05）。
结论
结果表明，IL-18 -607 A/C多态性杂合子患结直肠癌的风险增加。
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