Chan John K, Kapp Daniel S, Cheung Michael K, Shin Jacob Y, Stieglitz Deirdre, Husain Amreen, Teng Nelson N, Berek Jonathan S, Osann Kathryn, Guo Hongyan
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Services, University of California, San Francisco School of Medicine, Helen Diller Family Comprehensive Cancer Center, 94143-1702, USA.
Am J Obstet Gynecol. 2008 Feb;198(2):216.e1-5. doi: 10.1016/j.ajog.2007.08.028.
The purpose of this study was to evaluate the role of surgical staging in patients with grade 1 endometrioid uterine cancer.
Data were extracted from Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Kaplan-Meier and Cox proportional hazards analyses were used to determine predictors for disease-specific survival.
Twelve thousand seven hundred and twelve women were reported with endometrioid carcinoma, including 3867 with grade 1 disease, of which 25.5% had stage IC or more advanced disease, 15.4% with disease extending beyond the uterine corpus, 7.3% with extrauterine metastases, and 3.3% with lymph node metastases. On multivariate analysis, younger age and earlier stage remained as significant prognostic factors for improved survival.
Since grade 1 endometrioid uterine cancers have a 15.4% risk of extrauterine spread, a complete surgical staging procedure is recommended when clinically feasible. Younger age and earlier stage are significant prognostic factors for improved survival.
本研究旨在评估手术分期在1级子宫内膜样子宫癌患者中的作用。
数据取自1988年至2001年的监测、流行病学和最终结果计划。采用Kaplan-Meier法和Cox比例风险分析法确定疾病特异性生存的预测因素。
报告了12712例子宫内膜样癌女性患者，其中3867例为1级疾病，其中25.5%患有IC期或更晚期疾病，15.4%的疾病超出子宫体，7.3%有子宫外转移，3.3%有淋巴结转移。多因素分析显示，年龄较小和分期较早仍是生存改善的重要预后因素。
由于1级子宫内膜样子宫癌有15.4%的子宫外扩散风险，临床可行时建议进行完整的手术分期程序。年龄较小和分期较早是生存改善的重要预后因素。
