Migasena S, Pitisuttithum P, Desakorn V
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1991 Dec;22 Suppl:225-7.
An outbreak of Gnathostoma larva migrans occurred among guests of a New Year's party in Chachoengsao, Thailand. Nine people who consumed a raw fish dish called 'Hu-sae' contracted the disease. Five of them developed gastro-intestinal symptoms consisting of nausea, vomiting, abdominal cramps and diarrhea as early as within the first 24 hours, while in the other four, symptoms started on the following day. After the initial symptoms pertaining to the gut, malaise, chest discomfort, cough, myalgia, weakness, itching and migratory swellings were experienced. Eosinophilia was demonstrated in every patient with a mean (+/- SE) count of 5,516 +/- 1,010 cells/cu mm. Detection of antibody against aqueous extracts of G. spinigerum adult antigen using an enzyme-linked immunosorbent assay showed a titer of 1:1,600 or greater in every patients except one who had a titer of 1:400 (positive greater than or equal to 1:400). This outbreak illustrates the high attack rate when heavily infected fish are consumed.
泰国北柳府一场新年派对的宾客中爆发了颚口线虫幼虫移行症。9名食用了名为“Hu-sae”的生鱼菜肴的人感染了该病。其中5人在最初24小时内就出现了包括恶心、呕吐、腹部绞痛和腹泻在内的胃肠道症状，而另外4人在第二天开始出现症状。在最初的肠道症状之后，患者还经历了不适、胸部不适、咳嗽、肌痛、虚弱、瘙痒和游走性肿胀。每名患者均出现嗜酸性粒细胞增多，平均（±标准误）计数为5516±1010个细胞/立方毫米。使用酶联免疫吸附测定法检测针对棘颚口线虫成虫抗原水提取物的抗体，结果显示除1名滴度为1:400（阳性≥1:400）的患者外，其他每名患者的滴度均为1:1600或更高。此次疫情表明，食用受严重感染的鱼类时感染率很高。
