Hsu L L, Fox S W
Biosystems. 1976 Jul;8(2):89-101. doi: 10.1016/0303-2647(76)90012-5.
Experiments demonstrating an incorporation of different enzymelike activities into a single preparation of proteinoid microspheres provide a conceptual basis for the primitive lengthening of protometabolic pathways. An enhancement of one enzymelike activity by another proteinoid in the same microsphere has been found. This effect, plus the pathway-lengthening propensity of combinations of microspheres, indicates selective advantages contributing to adaptive protoselection. Data reported in this paper also bring into purview the concept of internally controlled variation. Inferences are derived for the origin of protosexuality in protocells. When allowance is made for a closer relationship to the environment than that needed in contemporary selection, the fundamental mechanistic requirements of protoevolution are regarded as met by the proteinoid microsphere.
实验表明，将不同的类酶活性整合到单一的类蛋白微球制剂中，为原始代谢途径的延长提供了概念基础。已发现在同一微球中，一种类蛋白可增强另一种类酶活性。这种效应，再加上微球组合延长途径的倾向，表明了有助于适应性原选择的选择性优势。本文报道的数据还引入了内部控制变异的概念。由此推导出原始细胞中原性别的起源。当考虑到与环境的关系比当代选择所需的关系更密切时，类蛋白微球被认为满足了原进化的基本机制要求。
