Zhou G, Ren S, Chen N, Duan L, Zhang Z, Fang S, Zhao W
Department of Geriatric Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, People's Republic of China.
J Int Med Res. 2008 Jan-Feb;36(1):115-22. doi: 10.1177/147323000803600115.
This study examined the association between cerebral white matter lesions (WMLs) and cognitive function in a male, non-demented Chinese veteran cohort. A total of 662 participants underwent CT scan and cognitive function assessments; 51 were excluded from the analysis because they exhibited non-lacunar infarcts or suspected dementia. Subjects were allocated to one of four groups according to WML status and between-group comparisons were made for seven cognitive function tests. Logistic regression was used to assess odds ratios for impaired performance associated with WML status. In all cognitive tests, subjects with severe WMLs differed significantly from those without WMLs or with mild WMLs, and in three tests subjects with severe WMLs differed significantly from those with moderate WMLs. For each cognitive test severe WMLs were strongly associated with increased risk of impaired performance. Severe WMLs were associated with greater diminished cognitive function and there may be a WML threshold after which, in elderly Chinese subjects, an impact on cognitive function occurs.
本研究在一个非痴呆的中国男性退伍军人队列中，考察了脑白质病变（WMLs）与认知功能之间的关联。共有662名参与者接受了CT扫描和认知功能评估；51人因出现非腔隙性梗死或疑似痴呆而被排除在分析之外。根据WML状态，将受试者分为四组之一，并对七项认知功能测试进行组间比较。采用逻辑回归评估与WML状态相关的表现受损的比值比。在所有认知测试中，重度WMLs受试者与无WMLs或轻度WMLs受试者有显著差异，在三项测试中，重度WMLs受试者与中度WMLs受试者有显著差异。对于每项认知测试，重度WMLs与表现受损风险增加密切相关。重度WMLs与更大程度的认知功能减退相关联，并且可能存在一个WML阈值，超过该阈值后，对中国老年受试者的认知功能会产生影响。
