Caunca Michelle R, De Leon-Benedetti Andres, Latour Lawrence, Leigh Richard, Wright Clinton B
Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences, Leonard M. Miller School of Medicine, Evelyn F. McKnight Brain Institute, University of Miami, Miami, FL, United States.
Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.
Front Aging Neurosci. 2019 Jun 27;11:145. doi: 10.3389/fnagi.2019.00145. eCollection 2019.
Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is thought to play a role in the pathogenesis of cognitive disorders. Identifying the etiologies of different types of lesions may help investigators differentiate between age-related and pathological cerebrovascular damage in cognitive aging. In this review article, we aim to describe the epidemiology and etiology of various brain magnetic resonance imaging (MRI) measures of vascular damage in cognitively normal, older adult populations. We focus here on population-based prospective cohort studies of cognitively unimpaired older adults, as well as discuss the heterogeneity of MRI findings and their relationships with cognition. This review article emphasizes the need for a better understanding of subclinical cerebrovascular disease in cognitively normal populations, in order to more effectively identify and prevent cognitive decline in our rapidly aging population.
亚临床脑血管疾病在神经影像学研究中经常被发现，并被认为在认知障碍的发病机制中起作用。确定不同类型病变的病因可能有助于研究人员区分认知老化中与年龄相关的和病理性的脑血管损伤。在这篇综述文章中，我们旨在描述认知正常的老年人群中各种脑磁共振成像（MRI）血管损伤测量指标的流行病学和病因。我们在此重点关注基于人群的认知未受损老年人前瞻性队列研究，并讨论MRI结果的异质性及其与认知的关系。这篇综述文章强调，需要更好地了解认知正常人群中的亚临床脑血管疾病，以便在我们快速老龄化的人群中更有效地识别和预防认知衰退。
