Grond S, Zech D, Schug S A, Lynch J, Lehmann K A
Department of Anaesthesiology, University of Cologne, Germany.
Int J Clin Pharmacol Res. 1991;11(6):253-60.
In a retrospective study of 1070 cancer patients being treated according to guidelines of the World Health Organization during a period of 55,285 days, the importance, efficacy and side-effects of non-opioid analgesics were evaluated. The non-opioids were given alone on 6917 days and in combination with weak opioids on 15,253 days, with strong opioids on 24,246 days and with spinal opioids on 1008 days. In evaluating efficacy and safety, it was not possible to differentiate adequately between the effects of non-opioids, opioids and adjuvant drugs, but it was demonstrated that an adequate combination of these drugs was effective and safe in the treatment of cancer pain.
在一项回顾性研究中，对1070例按照世界卫生组织指南接受治疗的癌症患者进行了为期55285天的观察，评估了非阿片类镇痛药的重要性、疗效和副作用。非阿片类药物单独使用6917天，与弱阿片类药物联合使用15253天，与强阿片类药物联合使用24246天，与脊髓阿片类药物联合使用1008天。在评估疗效和安全性时，无法充分区分非阿片类药物、阿片类药物和辅助药物的作用，但结果表明，这些药物的适当组合在治疗癌痛方面是有效且安全的。
