Reguiaï Ziad, Jovenin Nicolas, Bernard Philippe, Derancourt Christian
Service de Dermatologie, Hôpital Robert-Debré, Reims, France.
Dermatology. 2008;216(4):330-6. doi: 10.1159/000114207. Epub 2008 Jan 29.
Multiple solar lentigines of the upper back and shoulders (MSLBS) have recently been demonstrated as being associated with intense sunburns in the past.
To determine the prevalence of MSLBS among patients with cutaneous melanoma.
Thisprevalence study was conducted prospectively from October 2003 to November 2004 in a single department of dermatology (Reims University Hospital, north of France). One hundred and twenty-five adult patients, followed up for a cutaneous melanoma, were included, and the prevalence of MSLBS was determined, with comparison of clinical characteristics of patients with and without these lesions.
The prevalence of MSLBS among patients with cutaneous melanoma was 37.6%. MSLBS were significantly and independently associated with cutaneous melanoma of the back in multivariate analysis (adjusted odds ratio, OR = 4.3, 95% confidence interval, CI = 1.5-12.3) and with recalled episodes of severe sunburn before the age of 28 (OR = 3.4, 95% CI = 1.3-9.4).
Large irregularly shaped brown macules of the upper back and shoulders or MSLBS are frequent among adult patients with cutaneous melanoma. They are associated with melanoma located on the upper back. This topographical association further illustrates the relation between past intense sunburns and cutaneous melanoma. MSLBS should be evaluated as an easily recognizable clinical marker of the risk of cutaneous melanoma.
上背部和肩部的多发性日光性雀斑（MSLBS）最近已被证实与过去的严重晒伤有关。
确定皮肤黑色素瘤患者中MSLBS的患病率。
这项患病率研究于2003年10月至2004年11月在法国北部兰斯大学医院的单一皮肤科前瞻性进行。纳入了125名接受皮肤黑色素瘤随访的成年患者，确定了MSLBS的患病率，并比较了有和没有这些病变的患者的临床特征。
皮肤黑色素瘤患者中MSLBS的患病率为37.6%。在多变量分析中，MSLBS与背部皮肤黑色素瘤显著且独立相关（调整后的优势比，OR = 4.3，95%置信区间，CI = 1.5 - 12.3），并且与28岁之前回忆起的严重晒伤发作相关（OR = 3.4，95%CI = 1.3 - 9.4）。
上背部和肩部的大的不规则形状的褐色斑或MSLBS在成年皮肤黑色素瘤患者中很常见。它们与上背部的黑色素瘤相关。这种地形学关联进一步说明了过去严重晒伤与皮肤黑色素瘤之间的关系。MSLBS应被评估为皮肤黑色素瘤风险的一个易于识别的临床标志物。
