Borges D R, Kouyoumdjian M, Limãos E A
Disciplina de Gastroenterologia Clínica, Escola Paulista de Medicina, São Paulo, Brasil.
Braz J Med Biol Res. 1991;24(1):63-5.
Rat plasma kallikrein (RPK) is a serine protease that circulates as an inactive precursor, prokallikrein, and once activated is efficiently cleared by the liver by a carbohydrate-dependent, Ca(2+)-independent mechanism. Seven hepatic lectin systems have been described for mammals but not all of these animal lectins are expressed in the avian liver. Using a liver perfusion system we compared the plasma kallikrein clearance of rats (N = 10) and pigeons (N = 4). Our results show that the lectin responsible for the hepatic clearance of plasma kallikrein is also present in pigeon liver and that this organ clears the enzyme with an efficiency (11.4 +/- 1.3 pmol/g, 20 min) similar to that of the rat liver (10.0 +/- 0.7 pmol/g, 20 min).
大鼠血浆激肽释放酶（RPK）是一种丝氨酸蛋白酶，以无活性前体激肽释放酶原的形式循环，一旦被激活，肝脏会通过一种依赖碳水化合物、不依赖Ca(2+)的机制有效地清除它。哺乳动物已被描述有七种肝脏凝集素系统，但并非所有这些动物凝集素都在禽类肝脏中表达。我们使用肝脏灌注系统比较了大鼠（N = 10）和鸽子（N = 4）血浆激肽释放酶的清除情况。我们的结果表明，负责肝脏清除血浆激肽释放酶的凝集素也存在于鸽子肝脏中，并且该器官清除该酶的效率（11.4 +/- 1.3 pmol/g，20分钟）与大鼠肝脏相似（10.0 +/- 0.7 pmol/g，20分钟）。
