肝脏对血浆激肽释放酶与血浆激肽释放酶-α-巨球蛋白复合物清除率的比较。
Comparison between clearance rates of plasma kallikrein and of plasma kallikrein-alpha-macroglobulin complexes by the liver.
作者信息
Ogata H, Kouyoumdjian M, Borges D R
机构信息
Department of Biochemistry, Escola Paulista de Medicina, Såo Paulo, Brasil.
出版信息
Int J Biochem. 1993 Jul;25(7):1047-51. doi: 10.1016/0020-711x(93)90120-4.
PMID:7689988
Abstract
- alpha-Macroglobulins (alpha Ms) were isolated from the serum of injured rats through a two-stage method: gel filtration and ultracentrifugation. 2. The clearance rates of rat plasma kallikrein (RPK) and alpha Ms-RPK complexes were compared in an isolated rat liver perfusion system: the alpha Ms-RPK complexes are cleared at a much slower rate (half-life ranging from 24 to > 120 min) than does RPK itself (half-life ranging from 13 to 18 min).
摘要
- 通过凝胶过滤和超速离心的两阶段方法，从受伤大鼠的血清中分离出α-巨球蛋白（αMs）。2. 在离体大鼠肝脏灌注系统中比较了大鼠血浆激肽释放酶（RPK）和αMs-RPK复合物的清除率：αMs-RPK复合物的清除速度要比RPK本身慢得多（半衰期为24至>120分钟），RPK本身的半衰期为13至18分钟。
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