Ballauff A, Rascher W, Tölle H G, Wember T, Manz F
Research Institute of Child Nutrition, Dortmund, FRG.
Miner Electrolyte Metab. 1991;17(6):377-82.
Circadian rhythms of urine excretion, urine osmolality and renal excretion rates of sodium, chloride, potassium, creatinine and urea were studied for 3 days at home in 21 healthy children aged 6-11 years. Urine production as well as renal excretion rates of all solutes studied increased significantly during daytime and had minimum values at night. The peak of potassium and chloride excretion rates occurred earlier in the day than that of sodium. Considering all children together, no circadian rhythm was seen for urine osmolality. However, 9 children had evident but individually different rhythms of urine osmolality, changes which did not seem to correspond to the daily distribution of water intake. Circadian rhythmicity of urine osmolality and renal excretion rates of the main solutes should be considered in diagnostic and therapeutic procedures concerning fluid and electrolyte metabolism.
对21名6至11岁的健康儿童在家中进行了为期3天的研究，观察其尿液排泄、尿渗透压以及钠、氯、钾、肌酐和尿素的肾排泄率的昼夜节律。所有研究溶质的尿量生成以及肾排泄率在白天显著增加，夜间则降至最低值。钾和氯排泄率的峰值出现在一天中比钠更早的时间。综合所有儿童来看，尿渗透压未见昼夜节律。然而，9名儿童有明显但各自不同的尿渗透压节律变化，这些变化似乎与每日水摄入量的分布不相符。在有关液体和电解质代谢的诊断和治疗过程中，应考虑尿渗透压和主要溶质肾排泄率的昼夜节律性。
