Stanger Ben Z
Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Cell Cycle. 2008 Feb 1;7(3):318-24. doi: 10.4161/cc.7.3.5348. Epub 2007 Nov 21.
The size of an organism dictates both its functional challenges and how it meets them. Despite being a universal feature of all living creatures, how an organism determines its size, and that of its internal organs, is largely unknown. In particular, the mechanisms by which organs sense magnitude and alter cellular behavior to ensure symmetry, proportionality and correct final size are unknown. This review outlines our current understanding of the field and highlights several important outstanding questions.
生物体的大小决定了其面临的功能挑战以及应对这些挑战的方式。尽管这是所有生物的一个普遍特征，但生物体如何确定自身及其内部器官的大小在很大程度上仍不为人知。特别是，器官感知大小并改变细胞行为以确保对称性、比例性和最终正确大小的机制尚不清楚。本综述概述了我们目前对该领域的理解，并突出了几个重要的悬而未决的问题。
