Walschaerts Marie, Huyghe Eric, Muller Audrey, Bachaud Jean-Marc, Bujan Louis, Thonneau Patrick
Human Fertility Research Group (EA 3694), University Paul Sabatier-Toulouse III, INSERM, Toulouse Cedex 9, France.
Cancer Causes Control. 2008 Mar;19(2):155-61. doi: 10.1007/s10552-007-9081-x. Epub 2007 Nov 16.
In recent decades, testicular cancer incidence has considerably increased in a majority of industrialized countries. In France, short reports suggested that the testicular cancer incidence rate has also risen, especially in north-eastern regions. In Europe, geographical variation of incidence rates has been observed in Baltic countries and a clear birth cohort effect has been revealed. This study aimed to assess temporal trends in testicular cancer incidence in southern France. We examined incidence rates over a 20-year time period in a series of 506 consecutive cases of testicular cancer recorded from 1980 to 1999 in the Midi-Pyrenees region of France. Age, calendar period, and birth cohort effects were examined simultaneously using Poisson regression models. Our analysis found a significant rise in the overall incidence rate of testicular germ cell tumors from 1.27 to 3.04 per 100,000 between 1980-1984 and 1995-1999, an annual increase of 5.70%. These results, the first obtained in a large series in southern Europe, show a twofold increase in incidence rate of testicular cancer in the Midi-Pyrenees region, which is very similar to that observed in all European countries, more or less doubling in the last 20 years. Interestingly, this major jump and the apparent testicular cancer gradient between northern and southern Europe suggest considerable geographical heterogeneity in incidence, but low geographical variation in temporal trends.
近几十年来，大多数工业化国家的睾丸癌发病率大幅上升。在法国，简短报告表明睾丸癌发病率也有所上升，尤其是在东北部地区。在欧洲，波罗的海国家观察到发病率的地理差异，并且揭示了明显的出生队列效应。本研究旨在评估法国南部睾丸癌发病率的时间趋势。我们调查了1980年至1999年在法国南部-比利牛斯地区记录的一系列连续506例睾丸癌病例在20年期间的发病率。使用泊松回归模型同时检查年龄、日历时期和出生队列效应。我们的分析发现，1980 - 1984年至1995 - 1999年期间，睾丸生殖细胞肿瘤的总体发病率从每10万人1.27例显著上升至3.04例，年增长率为5.70%。这些结果是在南欧的一个大型系列研究中首次获得的，显示出南部-比利牛斯地区睾丸癌发病率增加了两倍，这与在所有欧洲国家观察到的情况非常相似，在过去20年中或多或少增加了一倍。有趣的是，这一重大跃升以及北欧和南欧之间明显的睾丸癌梯度表明发病率存在相当大的地理异质性，但时间趋势的地理差异较小。
