Urso C, Giannotti V, Reali U M, Giannotti B, Bondi R
Institute of Pathological Anatomy and Histology, University of Florence, Policlinico di Careggi, Italy.
Melanoma Res. 1991 Nov-Dec;1(4):245-9. doi: 10.1097/00008390-199111000-00004.
A series of 233 consecutive primary cutaneous melanomas was histologically and clinically studied. Histologically, 53 melanomas (22.7%) were associated with naevus cells. Such a high degree of association suggests that melanocytic naevus may be a precursor of a large number of melanomas. Analysing the cases according to Clark's levels and Breslow's index, a decrease in the naevus-melanoma association was seen with tumour progression, suggesting that advanced tumours may overgrow pre-existing nevus cells, appearing as de novo melanomas. The comparison between histological and clinical data suggest some interpretations of the natural history of melanoma.
对连续的233例原发性皮肤黑色素瘤进行了组织学和临床研究。组织学上，53例黑色素瘤（22.7%）与痣细胞有关。如此高的关联度表明黑素细胞痣可能是大量黑色素瘤的前驱病变。根据克拉克分级和布雷斯洛指数分析这些病例，发现随着肿瘤进展，痣与黑色素瘤的关联度降低，这表明进展期肿瘤可能会覆盖先前存在的痣细胞，表现为新发黑色素瘤。组织学和临床数据的比较提示了对黑色素瘤自然史的一些解读。
