Taber R, Alexander V, Wald N
Cell. 1976 Aug;8(4):529-33. doi: 10.1016/0092-8674(76)90221-x.
We have selected Chinese hamster ovary (CHO) cells resistant to infection by encephalomycarditis (EMC) virus. Thus far, we have obtained five lines resistant to EMC, all of which manifest different phenotypes. Three of the five are not persistently infected with virus, while two lines produce infectious virus and grow in its presence. The nonpersistently infected lines exhibit different resistance profiles to the other viruses we have tested, and they are stable in nonselective growth conditions. Their resistance appears to be due to a genetic alteration in the cell.
我们筛选出了对脑心肌炎（EMC）病毒感染具有抗性的中国仓鼠卵巢（CHO）细胞。到目前为止，我们已经获得了五条对EMC具有抗性的细胞系，它们均表现出不同的表型。五条细胞系中有三条不会持续感染病毒，而另外两条细胞系则会产生传染性病毒并在病毒存在的情况下生长。未被持续感染的细胞系对我们测试的其他病毒表现出不同的抗性特征，并且它们在非选择性生长条件下是稳定的。它们的抗性似乎是由于细胞中的基因改变所致。
