Taber R, Alexander V, Whitford W
J Virol. 1976 Feb;17(2):513-24. doi: 10.1128/JVI.17.2.513-524.1976.
We obtained a persistently infected line of Chinese hamster ovary cells by selection for resistance to reovirus infection. The cells were persistently infected by a population of viruses that were (i) cytopathic for parental chinese hamster ovary cells and (ii) similar to wild-type reovirus in molecular characteristics. The growth rate, plating efficiency, and morphology of the cells were altered. A large majority of the cells in the population were infected. There was no detectable interferon present in the medium. The cells were relatively resistant to a wide range of viruses.
我们通过选择对呼肠孤病毒感染具有抗性，获得了一株持续感染的中国仓鼠卵巢细胞系。这些细胞被一群病毒持续感染，这群病毒（i）对亲代中国仓鼠卵巢细胞具有细胞病变效应，（ii）在分子特征上与野生型呼肠孤病毒相似。细胞的生长速率、铺板效率和形态发生了改变。群体中的绝大多数细胞被感染。培养基中未检测到可检测的干扰素。这些细胞对多种病毒具有相对抗性。
